UK-1, a Novel Cytotoxic Metabolite from Streptomyces sp. 517-02. IV. Antifungal Action of Methyl UK-1.
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منابع مشابه
UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. VI(1). Structure-activity relationships of UK-2A.
UK-2A, B, C and D (UK-2 compounds) were isolated from Streptomyces sp. 517-02, and are similar to antimycin A3 (AA) in their structure and inhibitory activities towards electron transport at complex III in mitochondria1-3). However, the benzyl group at the C2 position in UK-2A (main component of UK-2 compounds) has never been found in known antimycins and a methyl group is lacking at the C8 pos...
متن کاملUK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties.
Novel antifungal antibiotics, UK-2A, B and a mixture of C and D, were obtained from the mycelial cake of Streptomyces sp. 517-02. All of the UK-2 compounds were similar in structure to antimycin A. The antifungal activities of UK-2 compounds were as strong as that of antimycin A. However, the UK-2 compounds demonstrated weak cytotoxicity compared to antimycin A.
متن کاملUK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. IV. Comparative studies of UK-2A with antimycin A3 on cytotoxic activity and reactive oxygen species generation in LLC-PK1 cells.
UK-2A, a novel antifungal antibiotic, is a structural relative of antimycin A3 (AA) and its mode of action is similar to that of AA which inhibits mitochondrial electron transport at complex III. In spite of their structural resemblance, AA had strong cytotoxicity while UK-2A had little cytotoxicity against LLC-PK1 cells as well as other types of cultured cells. When cells were treated with UK-...
متن کاملCytotoxic Activity of Bioactive Compound 1, 2- Benzene Dicarboxylic Acid, Mono 2- Ethylhexyl Ester Extracted from a Marine Derived Streptomyces sp. VITSJK8
Marine Streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. The cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (DMEHE) from marine derived actinomycete Streptomyces sp. VITSJK8 was investigated against mouse embryonic fi...
متن کاملThe mode of action of AKD-2C, an antifungal antibiotic from Streptomyces sp. OCU-42815.
The mechanism of the antifungal action of AKD-2C was studied by using Torulaspora delbrueckii IFO 1621 as a model. AKD-2C slightly inhibited the incorporation of radioactive precursors into protein, RNA and lipid, but not into DNA. On the other hand, AKD-2C greatly enhanced the leakage of K+ ions from treated cells and showed a potent effect on liposomal glucose leakage. Using electron microsco...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1998
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.51.883